NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N261360 |
Product Name: Anti-ATG7 (1F8) Mouse Monoclonal Antibody |
Synonyms: hAGP7; Ubiquitin-activating enzyme E1-like protein; APG7L |
UNIPROT ID: O95352 |
Background: The molecular machinery of autophagy was largely discovered in yeast and referred to as autophagy-related (Atg) genes. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10. |
Immunogen: Purified recombinant protein expressed in E.coli. |
Applications: IHC-P |
Recommended Dilutions: IHC: 1/50-1/100 |
Host Species: Mouse |
Clonality: Mouse Monoclonal |
Clone ID: 1F8-8H4-4G10 |
MW: – |
Isotype: IgG1 |
Purification: Affinity Purified |
Species Reactivity: Human,Rat,Mouse |
Conjugation: Unconjugated |
Modification: Unmodified |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
Research Areas: Cell Biology |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin-embedded Human Breast Carcinoma Tissue using ATG7 (1F8) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. |