Email: info@neweastbio.com   |  Call: 6109452007

NMDAR2B Rabbit pAb

Anti-NMDAR2B Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225335

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225335
Product Name:   Anti-NMDAR2B Rabbit pAb
Synonyms:   glutamate receptor; ionotropic; N-methyl D-aspartate 2B; MRD6; NR2B; hNR3; GluN2B; NMDAR2B
UNIPROT ID:   Q13224
Background:    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
Immunogen:    Synthetic peptide of human GRIN2B
Applications:    ICC/IF
Recommended Dilutions:    ICC: 1/100-1/200
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:   
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunofluorescence analysis of NMDAR2B (red) in Hela cells using NMDAR2B antibody.
          Publications