NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N225413 | ||||
Product Name: Anti-Cleaved-Caspase 6 p18 Rabbit pAb | ||||
Synonyms: CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2 | ||||
UNIPROT ID: P55212 | ||||
Background: Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A. | ||||
Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 6. AA range:130-179 | ||||
Applications: WB,IHC-P,ELISA | ||||
Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000 | ||||
Host Species: Rabbit | ||||
Clonality: Rabbit Polyclonal | ||||
Clone ID: – | ||||
MW: Calculated MW: 33 kDa; Observed MW: 20,35 kDa | ||||
Isotype: IgG | ||||
Purification: Affinity Chromatography | ||||
Species Reactivity: Human,Rat | ||||
Conjugation: Unconjugated | ||||
Modification: Cleaved | ||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||
Research Areas: apoptosis – Caspase family | ||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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