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Lamin A/C (5D12) Mouse mAb

Anti-Lamin A/C (5D12) Mouse Monoclonal Antibody
5/5

$349.00

Cat.#:  N261447

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261447
Product Name:   Anti-Lamin A/C (5D12) Mouse Monoclonal Antibody
Synonyms:   LMNA; LMN1; Prelamin-A/C
UNIPROT ID:   P02545
Background:    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Immunogen:    Purified recombinant human LMNA protein fragments expressed in E.coli.
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Mouse
Clonality:    Mouse Monoclonal
Clone ID:    5D12-C6-E9
MW:    Calculated MW: 74 kDa; Observed MW: 63,74 kDa
Isotype:    IgG1
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Tags & Cell Markers
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunofluorescence analysis of Lamin A/C (5D12) in A549 using Lamin A/C antibody.

Western blot analysis of Lamin A/C in MCF-7, A549 and Hela lysates using Lamin A/C antibody.
          Publications