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HP1 alpha Rabbit mAb

Anti-HP1 alpha Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262357

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262357
Product Name:   Anti-HP1 alpha Rabbit Monoclonal Antibody
Synonyms:   CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
UNIPROT ID:   P45973
Background:    Component of heterochromatin that recognizes and binds histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Immunogen:    A synthetic peptide of human HP1 alpha
Applications:    WB,IHC-F,IHC-P,ICC/IF,IP
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R09-9D5
MW:    Calculated MW: 22 kDa; Observed MW: 22 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunocytochemistry analysis of HP1 alpha(green) in Hela using HP1 alpha antibody,and DAPI(blue)

Western blot analysis of HP1 alpha in C6, PC-12 lysates using HP1 alpha antibody.

Western blot analysis of HP1 alpha in 3T3, Hela lysates using HP1 alpha antibody.

Immunohistochemistry analysis of paraffin-embedded Human colon cancer using HP1 alpha antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
          Publications