Email: info@neweastbio.com   |  Call: 6109452007

IRF8 Rabbit mAb

Anti-IRF8 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262424

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262424
Product Name:   Anti-IRF8 Rabbit Monoclonal Antibody
Synonyms:   ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
UNIPROT ID:   Q02556
Background:    Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5′-TGAnTCA/GAAA-3′), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes .
Immunogen:    Recombinant protein of human IRF8
Applications:    WB,IHC-P,IP
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R07-8I1
MW:    Calculated MW: 48 kDa; Observed MW: 48 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of IRF8 in THP-1 lysates using IRF8 antibody.
          Publications