NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N263044 | ||
Product Name: Anti-U1C Rabbit Monoclonal Antibody | ||
Synonyms: U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C | ||
UNIPROT ID: P09234 | ||
Background: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5′ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5′ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5′ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5′ end of the U1 snRNA and the 5′ splice-site region. | ||
Immunogen: A synthetic peptide of human U1-C | ||
Applications: WB,IHC-F,IHC-P,ICC/IF,IP | ||
Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 | ||
Host Species: Rabbit | ||
Clonality: Rabbit Monoclonal | ||
Clone ID: R09-6E9 | ||
MW: Calculated MW: 17 kDa; Observed MW: 21 kDa | ||
Isotype: IgG | ||
Purification: Affinity Purified | ||
Species Reactivity: Human,Rat | ||
Conjugation: Unconjugated | ||
Modification: Unmodified | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
Research Areas: Epigenetics and Nuclear Signaling | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
|