NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N263229 | ||||
Product Name: Anti-ATP6V1A Rabbit Monoclonal Antibody | ||||
Synonyms: HO68; VA68; VPP2; Vma1; ARCL2D; ATP6A1; IECEE3; ATP6V1A1 | ||||
UNIPROT ID: P38606 | ||||
Background: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). | ||||
Immunogen: Recombinant protein of human ATP6V1A | ||||
Applications: WB,IHC-P,IP | ||||
Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20 | ||||
Host Species: Rabbit | ||||
Clonality: Rabbit Monoclonal | ||||
Clone ID: R03-5H1 | ||||
MW: Calculated MW: 68 kDa; Observed MW: 68 kDa | ||||
Isotype: IgG | ||||
Purification: Affinity Purified | ||||
Species Reactivity: Human,Mouse,Rat | ||||
Conjugation: Unconjugated | ||||
Modification: Unmodified | ||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||
Research Areas: Tags & Cell Markers | ||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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