NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$239.00
Cat. #: 26007 |
Gene Symbol: RHOA |
Description: Anti-RhoA Mouse Monoclonal Antibody |
Background: Small GTPases are a super-family of cellular signaling regulators. RhoA belongs to the Rho sub-family of GTPases. Rho proteins play critical roles in many actin cytoskeleton- dependent processes including platelet aggregation, cell motility, contraction, and cytokinesis. It regulates the formation of stress fibers and focal adhesions in fibroblasts and Ca2+ sensitivity of smooth muscle contraction. |
Immunogen: : Recombinant full length protein of RhoA. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA 1:1000-1:5000 WB 1:1000-1:2000 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: : PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: RhoA antibody recognizes RhoA from vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
1. Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds Commun Biol. 2021 PMID: 34145387 |
2. Acute compressive stress activates RHO/ROCK-mediated cellular processes Small GTPases 2020 PMID: 29455593 |
3. Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells FASEB J. 2018 PMID: 29447006 |
4. Social Isolation Induces Rac1-Dependent Forgetting of Social Memory Cell Rep. 2018 PMID: 30304669 |
5. The Heterotaxy Gene CCDC11 is Essential for Cytokinesis and Cell-Cell Adhesion via RhoA Regulation bioRxiv. 2018 PMID: |
6. Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers Gastroenterology. 2017 PMID: 28522256 |