NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
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Virus-like particles (VLPs) are self-assembling multi-protein nanoparticles with similar structural organization and conformation as viruses but without viral genome. The size of the VLP is about 100-150nm. It is secreted from the surface of the cells that express target membrane proteins (MPs). The purified VLPs have the target MPs inserted in a complete bilayer phospholipid membrane structure, mimic the natural membrane-penetrating state of the protein.