NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$445.00
Cat.#: 28373 | ||||
Product Name: Anti-4-1BB(DM66) Rabbit Monoclonal Antibody | ||||
Synonyms: TNFRSF9; 4-1BB; CD137; CDw137; ILA | ||||
Description: Anti-4-1BB antibody(DM66) Rabbit Monoclonal Antibody | ||||
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion; survival; and development of T cells. It can also induce proliferation in peripheral monocytes; enhance T cell apoptosis induced by TCR:CD3 triggered activation; and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. | ||||
Applications: ELISA; Flow Cyt | ||||
Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100 | ||||
Host Species: Rabbit | ||||
Isotype: Rabbit IgG | ||||
Purification: Purified from cell culture supernatant by affinity chromatography | ||||
Species Reactivity: Human 4-1BB | ||||
Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. | ||||
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). | ||||
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