NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$495.00
ALK(D1225N)
Cat. #: 26290 |
Gene Symbol: ALK, CD246, NBLST3 |
Description: Anti-ALK(D1225N) Mouse Monoclonal Antibody |
Background: Anaplastic lymphoma kinase (ALK) also known as CD246 (cluster of differentiation 246) is a tyrosine kinase receptor that plays an important role in the development of the brain and nervous systems. Deficiencies in ALK, which most commonly as a fusion with other genes, are indicated in cancers. |
Immunogen: A synthetic peptide from the internal region of ALK which includes the mutation of D1225N, human origin. |
Applications: ELISA, WB |
Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:500-1:2000 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes D1225N mutant, but not wild type ALK of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Western blot analysis of recombinant ALK(D1225N) and wild type proteins. Purified His-tagged ALK(D1225N) protein (1060-1620aa, 68KD, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-ALK(D1225N) monoclonal antibody (Cat. #26290). |