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A2M Rabbit pAb

Anti-A2M Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221295

   Size:   100 μl

In Stock

            Product Description          
Cat.#:   S221295
Product Name:   Anti-A2M Rabbit Polyclonal Antibody
Synonyms:   A2MD; CPAMD5; FWP007; S863-7
UNIPROT ID:   P01023 (Gene Accession – NP_000005 )
Background:    The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer’s disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Immunogen:    Synthetic peptide of human A2M
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cell Biology, Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing
Immunohistochemistry analysis of paraffin embedded Human prostate cancer tissue using 221295(A2M Antibody) at a dilution of 1/50(Secreted). In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with the synthetic peptide and then with 221295(Anti-A2M Antibody) at dilution 1/50.
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