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ABCB11 Rabbit pAb

Anti-ABCB11 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220027

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220027
Product Name:   Anti-ABCB11 Rabbit Polyclonal Antibody
Synonyms:   BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2
UNIPROT ID:   O95342 (Gene Accession – NP_003733 )
Background:    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
Immunogen:    Synthetic peptide of human ABCB11
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 15-50; ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human ovarian cancer tissue using 220027(ABCB11 Antibody) at a dilution of 1/15(Cytoplasm ).

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with the synthetic peptide and then with 220027(Anti-ABCB11 Antibody) at dilution 1/15.

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using 220027(Anti-ABCB11 Antibody) at a dilution of 1/15.

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with synthetic peptide and then with D260801(Anti-ABCB11 Antibody) at dilution 1/15.
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