Email: info@neweastbio.com   |  Call: 6109452007

ADAMTS5 Rabbit pAb

Anti-ADAMTS5 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219655

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219655
Product Name:   Anti-ADAMTS5 Rabbit Polyclonal Antibody
Synonyms:   ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
UNIPROT ID:   Q9UNA0 (Gene Accession – NP_008969 )
Background:    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.
Immunogen:    Synthetic peptide of human ADAMTS5
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 219655(ADAMTS5 Antibody) at a dilution of 1/40(Secreted).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 219655(Anti-ADAMTS5 Antibody) at dilution 1/40.
          Publications