NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: S221305 | ||
Product Name: Anti-AGAP4 Rabbit Polyclonal Antibody | ||
Synonyms: AGAP8; MRIP2; AGAP-4; AGAP-8; CTGLF1; CTGLF5 | ||
UNIPROT ID: Q96P64 (Gene Accession – NP_001263272 ) | ||
Background: AGAP4(also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4) is a GTPase activating protein. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. AGAP4 and other AGAP proteins likely function in the secretory pathway, which could explain a link with the invasive behavior of cancer cells. Reliable antibodies would be invaluable for studies of the physiologic function of the proteins and how is may be linked to cancer cell invasive behavior. | ||
Immunogen: Synthetic peptide of human AGAP4 | ||
Applications: ELISA, IHC | ||
Recommended Dilutions: IHC: 20-100; ELISA: 5000-10000 | ||
Host Species: Rabbit | ||
Clonality: Rabbit Polyclonal | ||
Isotype: Immunogen-specific rabbit IgG | ||
Purification: Antigen affinity purification | ||
Species Reactivity: Human | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||
Research Areas: Signal Transduction | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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