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AIM2 Rabbit pAb

Anti-AIM2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S210945

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S210945
Product Name:   Anti-AIM2 Rabbit Polyclonal Antibody
Synonyms:   PYHIN4
UNIPROT ID:   O14862 (Gene Accession – BC010940 )
Background:    Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-?, AIM2 is thought to act as a tumor suppressor by repressing NF?B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of †-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.
Immunogen:    Fusion protein of human AIM2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 210945(AIM2 Antibody) at a dilution of 1/60(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 210945(Anti-AIM2 Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using 210945(Anti-AIM2 Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with fusion protein and then with D121935(Anti-AIM2 Antibody) at dilution 1/60.
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