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ALOX5 Rabbit pAb

Anti-ALOX5 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216243

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216243
Product Name:   Anti-ALOX5 Rabbit Polyclonal Antibody
Synonyms:   5-LO, 5LPG, LOG5, 5-LOX
UNIPROT ID:   P09917 (Gene Accession – BC130332 )
Background:    This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen:    Fusion protein of human ALOX5
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 500-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism, Cancer, Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human lung cancer tissue using 216243(ALOX5 Antibody) at a dilution of 1/25(Cytoplasm).

Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer tissue using 216243(Anti-ALOX5 Antibody) at a dilution of 1/25.
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