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ATM Rabbit mAb

Anti-ATM Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N261632

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261632
Product Name:   Anti-ATM Rabbit Monoclonal Antibody
Synonyms:   ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
UNIPROT ID:   Q13315
Background:    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.
Immunogen:    A synthetic peptide of human ATM
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R08-8H3
MW:    Calculated MW: 351 kDa; Observed MW: 351 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of ATM in Hela, 293 lysates using ATM antibody.

Immunocytochemistry analysis of ATM (green) in HT-1080 using ATM antibody,and DAPI(blue).
          Publications