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BAGE2 Rabbit pAb

Anti-BAGE2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221606

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221606
Product Name:   Anti-BAGE2 Rabbit Polyclonal Antibody
Synonyms:   CT2.2
UNIPROT ID:   Q86Y30
Background:    Members of the BAGE gene family encode antigens that are recognized by cytotoxic T lymphocytes and are also known as CT (cancer/testis) antigens. Generated by juxtacentromeric shuffling of the MLL3 gene, the ancestral BAGE gene was expanded by acrocentric exchanges and/or juxtacentromeric movements.Generally, BAGE proteins are silent in all normal tissues with the exception of testis. BAGE2(B melanoma antigen 2), also known as Cancer/testis antigen 2.2, is 109 amino acid secreted proteins that is expressed in 22% of melanomas, lung and bladder carcinomas, and is also expressed in normal testis tissue. Like the genes encoding MAGE proteins, BAGE genes are most likely silenced by DNA methylation and/or chromatin compaction in normal tissues other than testis.
Immunogen:    Synthetic peptide of human BAGE2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 221606(BAGE2 Antibody) at a dilution of 1/25(Secreted).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the synthetic peptide and then with 221606(Anti-BAGE2 Antibody) at dilution 1/25.
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