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BCR Rabbit pAb

Anti-BCR Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220101

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220101
Product Name:   Anti-BCR Rabbit Polyclonal Antibody
Synonyms:   ALL; CML; PHL; BCR1; D22S11; D22S662
UNIPROT ID:   P11274 (Gene Accession – NP_004318 )
Background:    A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen:    Synthetic peptide of human BCR
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gasrtic cancer tissue using 220101(BCR Antibody) at a dilution of 1/15(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human gasrtic cancer tissue is first treated with the synthetic peptide and then with 220101(Anti-BCR Antibody) at dilution 1/15.

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 220101(Anti-BCR Antibody) at a dilution of 1/15.

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with synthetic peptide and then with D260957(Anti-BCR Antibody) at dilution 1/15.
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