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BRCA2 Rabbit pAb

Anti-BRCA2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219679

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219679
Product Name:   Anti-BRCA2 Rabbit Polyclonal Antibody
Synonyms:   FAD, FACD, FAD1, GLM3, BRCC2, FANCB, FANCD, PNCA2, FANCD1, BROVCA2
UNIPROT ID:   P51587 (Gene Accession – NP_000050 )
Background:    Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Immunogen:    Synthetic peptide of human BRCA2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 219679(BRCA2 Antibody) at a dilution of 1/35(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 219679(Anti-BRCA2 Antibody) at dilution 1/35.
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