Email: info@neweastbio.com   |  Call: 6109452007

CASP4 Rabbit pAb

Anti-CASP4 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221525

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221525
Product Name:   Anti-CASP4 Rabbit Polyclonal Antibody
Synonyms:   TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II
UNIPROT ID:   P49662 (Gene Accession – NP_001216 )
Background:    This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Immunogen:    Synthetic peptide of human CASP4
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 221525(CASP4 Antibody) at a dilution of 1/25(Cytoplasm and Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 221525(Anti-CASP4 Antibody) at dilution 1/25.

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 221525(Anti-CASP4 Antibody) at a dilution of 1/25.

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with synthetic peptide and then with D263160(Anti-CASP4 Antibody) at dilution 1/25.
          Publications