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CCM2 Rabbit pAb

Anti-CCM2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S212176

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S212176
Product Name:   Anti-CCM2 Rabbit Polyclonal Antibody
Synonyms:   OSM; C7orf22; PP10187
UNIPROT ID:   Q9BSQ5 (Gene Accession – BC004903 )
Background:    This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen:    Fusion protein of human CCM2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 212176(CCM2 Antibody) at a dilution of 1/30(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 212176(Anti-CCM2 Antibody) at dilution 1/30.
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