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CD135 Rabbit pAb

Anti-CD135 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225195

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225195
Product Name:   Anti-CD135 Rabbit pAb
Synonyms:   FLT3; CD135; FLK2; STK1; Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD antigen CD135
UNIPROT ID:   P36888
Background:    This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Immunogen:    The antiserum was produced against synthesized peptide derived from the Internal region of human FLT3. AA range:451-500
Applications:    WB,ELISA
Recommended Dilutions:    WB: 1/500-1/1000 ELISA: 1/10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 113 kDa; Observed MW: 110 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of CD135 in 4T1 lysates using CD135 antibody.
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