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CDH12 Rabbit pAb

Anti-CDH12 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221706

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221706
Product Name:   Anti-CDH12 Rabbit Polyclonal Antibody
Synonyms:   CDHB
UNIPROT ID:   P55289 (Gene Accession – NP_004052 )
Background:    This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Immunogen:    Synthetic peptide of human CDH12
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 221706(CDH12 Antibody) at a dilution of 1/60(Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 221706(Anti-CDH12 Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 221706(Anti-CDH12 Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D263414(Anti-CDH12 Antibody) at dilution 1/60.
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