Email: info@neweastbio.com   |  Call: 6109452007

CDH3 Rabbit pAb

Anti-CDH3 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216714

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216714
Product Name:   Anti-CDH3 Rabbit Polyclonal Antibody
Synonyms:   CDHP; HJMD; PCAD
UNIPROT ID:   P22223 (Gene Accession – BC014462 )
Background:    This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS).
Immunogen:    Fusion protein of human CDH3
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 500-2000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 216714(CDH3 Antibody) at a dilution of 1/90(Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the fusion protein and then with 216714(Anti-CDH3 Antibody) at dilution 1/90.

Gel: 6%SDS-PAGE, Lysate: 40 μg;
Lane 1-2: K562 and 293T cell lysates;
Primary antibody: 216714(CDH3 Antibody) at dilution 1/500;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 5 seconds
          Publications