Email: info@neweastbio.com   |  Call: 6109452007

CDK12 Rabbit pAb

Anti-CDK12 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220478

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220478
Product Name:   Anti-CDK12 Rabbit Polyclonal Antibody
Synonyms:   CRK7; CRKR; CRKRS
UNIPROT ID:   Q9NYV4 (Gene Accession – NP_055898 )
Background:    Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates ‘Ser-5’ in CTD repeats that are already phosphorylated at ‘Ser-7’, but can also phosphorylate ‘Ser-2’. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Immunogen:    Synthetic peptide of human CDK12
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 220478(CDK12 Antibody) at a dilution of 1/50(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the synthetic peptide and then with 220478(Anti-CDK12 Antibody) at dilution 1/50.
          Publications