NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N261047 | ||
Product Name: Anti-CDK5 (2E8) Mouse Monoclonal Antibody | ||
Synonyms: Cdk 5; Cdk5; CDK5_HUMAN; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Cyclin-dependent kinase 5; Protein kinase CDK5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit. | ||
UNIPROT ID: Q00535 | ||
Background: Activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. | ||
Immunogen: Purified recombinant human CDK5(N-terminus) protein fragments expressed in E.coli. | ||
Applications: WB,ICC/IF | ||
Recommended Dilutions: WB: 1/500-1/1000 IF: 1/50-1/200 | ||
Host Species: Mouse | ||
Clonality: Mouse Monoclonal | ||
Clone ID: 2E8-F9-B7-C11 | ||
MW: Calculated MW: 33 kDa; Observed MW: 36 kDa | ||
Isotype: IgG1 | ||
Purification: Affinity Purified | ||
Species Reactivity: Human,Mouse,Rat,Monkey | ||
Conjugation: Unconjugated | ||
Modification: Unmodified | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
Research Areas: NeuroscienceyyyyyAlzheimer’s disease | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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