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CERS4 Rabbit pAb

Anti-CERS4 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220669

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220669
Product Name:   Anti-CERS4 Rabbit Polyclonal Antibody
Synonyms:   Trh1; LASS4
UNIPROT ID:   Q9HA82 (Gene Accession – NP_078828 )
Background:    The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.
Immunogen:    Synthetic peptide of human CERS4
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human ovarian cancer tissue using 220669(CERS4 Antibody) at a dilution of 1/35(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with the synthetic peptide and then with 220669(Anti-CERS4 Antibody) at dilution 1/35.

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 220669(Anti-CERS4 Antibody) at a dilution of 1/35.

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with synthetic peptide and then with D261849(Anti-CERS4 Antibody) at dilution 1/35.
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