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CHADL Rabbit pAb

Anti-CHADL Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221729

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221729
Product Name:   Anti-CHADL Rabbit Polyclonal Antibody
Synonyms:   SLRR4B
UNIPROT ID:   Q6NUI6 (Gene Accession – NP_612490 )
Background:    Members of the small leucine-rich proteoglycan (SLRP) family are mostly extracellular proteins that function upstream of multiple signaling cascades. They affect intracellular phosphorylation and modulate distinct pathways, such as those driven by Toll-like receptors, TGF? and receptor tyrosine kinases. As a member of the SLRP family, CHADL (Chondroadherin-like protein) is a 762 amino acid protein containing 21 LRR (leucine-rich) repeats, which promote protein-ligand interactions. Chondroadherin, a closely related protein, promotes attachment of chrondocytes, osteoblasts and fibroblasts and also plays an important role in the regulation of chrodrocyte proliferation and growth. CHADL is a secreted protein that is located in the extracellular space. There are two isoforms of CHADL that exist as a result of alternative splicing events. Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte’s differentiation by acting on its cellular collagenous microenvironment.
Immunogen:    Synthetic peptide of human CHADL
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: Oct-50; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Stem Cells
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 221729(CHADL Antibody) at a dilution of 1/30(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 221729(Anti-CHADL Antibody) at dilution 1/30.
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