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CHM Rabbit pAb

Anti-CHM Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221731

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221731
Product Name:   Anti-CHM Rabbit Polyclonal Antibody
Synonyms:   TCD; GGTA; REP-1; DXS540; HSD-32
UNIPROT ID:   P24386 (Gene Accession – NP_000381 )
Background:    This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.
Immunogen:    Synthetic peptide of human CHM
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colorectal cancer tissue using 221731(CHM Antibody) at a dilution of 1/85(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with the synthetic peptide and then with 221731(Anti-CHM Antibody) at dilution 1/85.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 221731(Anti-CHM Antibody) at a dilution of 1/85.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D263451(Anti-CHM Antibody) at dilution 1/85.
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