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Cleaved-Notch1 Rabbit pAb

Anti-Cleaved-Notch1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225351

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225351
Product Name:   Anti-Cleaved-Notch1 Rabbit pAb
Synonyms:   NOTCH1; TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1
UNIPROT ID:   P46531
Background:    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
Immunogen:    The antiserum was produced against synthesized peptide derived from human Notch 1. AA range:1735-1784
Applications:    WB,ICC/IF,IHC-F,IHC-P,ELISA
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 273 kDa; Observed MW: 110 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Cleaved
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Cleaved-Notch1 in various lysates using Cleaved-Notch1 antibody.
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