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CLK2 Rabbit pAb

Anti-CLK2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S214112

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S214112
Product Name:   Anti-CLK2 Rabbit Polyclonal Antibody
Synonyms:   
UNIPROT ID:   P49760 (Gene Accession – NP_003984 )
Background:    This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal comple,x thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.
Immunogen:    Synthetic peptide of human CLK2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 214112(CLK2 Antibody) at a dilution of 1/45(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 214112(Anti-CLK2 Antibody) at dilution 1/45.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 214112(Anti-CLK2 Antibody) at a dilution of 1/45.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D161363(Anti-CLK2 Antibody) at dilution 1/45.
          Publications