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CYFIP1 Rabbit pAb

Anti-CYFIP1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218561

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218561
Product Name:   Anti-CYFIP1 Rabbit Polyclonal Antibody
Synonyms:   SHYC; SRA1; SRA-1; P140SRA-1
UNIPROT ID:   Q7L576 (Gene Accession – BC005097 )
Background:    Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
Immunogen:    Fusion protein of human CYFIP1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 500-1000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 218561(CYFIP1 Antibody) at a dilution of 1/30(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 218561(Anti-CYFIP1 Antibody) at dilution 1/30.
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