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CYP17A1 Rabbit pAb

Anti-CYP17A1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217326

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217326
Product Name:   Anti-CYP17A1 Rabbit Polyclonal Antibody
Synonyms:   CPT7; CYP17; S17AH; P450C17
UNIPROT ID:   P05093 (Gene Accession – BC063388 )
Background:    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Immunogen:    Fusion protein of human CYP17A1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism, Signal Transduction, Cancer, Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 217326(CYP17A1 Antibody) at a dilution of 1/20(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 217326(Anti-CYP17A1 Antibody) at dilution 1/20.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 217326(Anti-CYP17A1 Antibody) at a dilution of 1/20.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with fusion protein and then with D222184(Anti-CYP17A1 Antibody) at dilution 1/20.
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