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DCC Rabbit pAb

Anti-DCC Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220067

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220067
Product Name:   Anti-DCC Rabbit Polyclonal Antibody
Synonyms:   CRC18; CRCR1; MRMV1; IGDCC1
UNIPROT ID:   P43146 (Gene Accession – NP_005206 )
Background:    This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Immunogen:    Synthetic peptide of human DCC
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gasrtic cancer tissue using 220067(DCC Antibody) at a dilution of 1/70(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human gasrtic cancer tissue is first treated with the synthetic peptide and then with 220067(Anti-DCC Antibody) at dilution 1/70.

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 220067(Anti-DCC Antibody) at a dilution of 1/70.

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with synthetic peptide and then with D260896(Anti-DCC Antibody) at dilution 1/70.
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