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DCPS Rabbit pAb

Anti-DCPS Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218580

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218580
Product Name:   Anti-DCPS Rabbit Polyclonal Antibody
Synonyms:   ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
UNIPROT ID:   Q96C86 (Gene Accession – BC014532 )
Background:    Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3′->5′ exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5′-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5′->3 mRNA decay pathway; m7GDP, the downstream product released by the 5′->3′ mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
Immunogen:    Fusion protein of human DCPS
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 218580(DCPS Antibody) at a dilution of 1/100(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 218580(Anti-DCPS Antibody) at dilution 1/100.

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 218580(Anti-DCPS Antibody) at a dilution of 1/100.

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with fusion protein and then with D224747(Anti-DCPS Antibody) at dilution 1/100.
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