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DENND1A Rabbit pAb

Anti-DENND1A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218604

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218604
Product Name:   Anti-DENND1A Rabbit Polyclonal Antibody
Synonyms:   FAM31A; KIAA1608
UNIPROT ID:   Q8TEH3 (Gene Accession – BC039703 )
Background:    Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).
Immunogen:    Fusion protein of human DENND1A
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 218604(DENND1A Antibody) at a dilution of 1/50(Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the fusion protein and then with 218604(Anti-DENND1A Antibody) at dilution 1/50.
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