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DENND1B Rabbit pAb

Anti-DENND1B Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S212319

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S212319
Product Name:   Anti-DENND1B Rabbit Polyclonal Antibody
Synonyms:   FAM31B; C1ORF18; C1orf218
UNIPROT ID:   Q6P3S1 (Gene Accession – BC063877 )
Background:    Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).
Immunogen:    Fusion protein of human DENND1B
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 212319(DENND1B Antibody) at a dilution of 1/20(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 212319(Anti-DENND1B Antibody) at dilution 1/20.
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