Cat.#: S210280 |
Product Name: Anti-DKK2 Rabbit Polyclonal Antibody |
Synonyms: DKK-2 |
UNIPROT ID: Q9UBU2 (Gene Accession – BC126328 ) |
Background: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). |
Immunogen: Fusion protein of human DKK2 |
Applications: ELISA, IHC |
Recommended Dilutions: IHC: 50-200; ELISA: 2000-5000 |
Host Species: Rabbit |
Clonality: Rabbit Polyclonal |
Isotype: Immunogen-specific rabbit IgG |
Purification: Antigen affinity purification |
Species Reactivity: Human, Mouse |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
Research Areas: Signal Transduction |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 210280(DKK2 Antibody) at a dilution of 1/60(Cytoplasm). | In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 210280(Anti-DKK2 Antibody) at dilution 1/60. |
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