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DNMT3A Rabbit pAb

Anti-DNMT3A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217054

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217054
Product Name:   Anti-DNMT3A Rabbit Polyclonal Antibody
Synonyms:   DNMT3A2; M.HsaIIIA
UNIPROT ID:   Q9Y6K1 (Gene Accession – BC043617 )
Background:    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen:    Fusion protein of human DNMT3A
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 217054(DNMT3A Antibody) at a dilution of 1/50(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 217054(Anti-DNMT3A Antibody) at dilution 1/50.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 217054(Anti-DNMT3A Antibody) at a dilution of 1/50.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with fusion protein and then with D221710(Anti-DNMT3A Antibody) at dilution 1/50.
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