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DSP Rabbit pAb

Anti-DSP Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S214295

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S214295
Product Name:   Anti-DSP Rabbit Polyclonal Antibody
Synonyms:   DP; DPI; DPII
UNIPROT ID:   P15924 (Gene Accession – NP_004406 )
Background:    Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Immunogen:    Synthetic peptide of human DSP
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 214295(DSP Antibody) at a dilution of 1/15(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 214295(Anti-DSP Antibody) at dilution 1/15.

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using 214295(Anti-DSP Antibody) at a dilution of 1/15.

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with synthetic peptide and then with D161631(Anti-DSP Antibody) at dilution 1/15.
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