Email: info@neweastbio.com   |  Call: 6109452007

ERN2 Rabbit pAb

Anti-ERN2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220530

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220530
Product Name:   Anti-ERN2 Rabbit Polyclonal Antibody
Synonyms:   IRE1b; IRE1-BETA
UNIPROT ID:   Q76MJ5 (Gene Accession – NP_150296 )
Background:    The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1à and IRE1? are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
Immunogen:    Synthetic peptide of human ERN2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 220530(ERN2 Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 220530(Anti-ERN2 Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 220530(Anti-ERN2 Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D261658(Anti-ERN2 Antibody) at dilution 1/40.
          Publications