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F13A1 Rabbit pAb

Anti-F13A1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220228

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220228
Product Name:   Anti-F13A1 Rabbit Polyclonal Antibody
Synonyms:   F13A
UNIPROT ID:   P00488 (Gene Accession – NP_000120 )
Background:    This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Immunogen:    Synthetic peptide of human F13A1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 220228(F13A1 Antibody) at a dilution of 1/80(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 220228(Anti-F13A1 Antibody) at dilution 1/80.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 220228(Anti-F13A1 Antibody) at a dilution of 1/80.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D261169(Anti-F13A1 Antibody) at dilution 1/80.
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