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Factor VIII Rabbit pAb

Anti-Factor VIII Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225444

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225444
Product Name:   Anti-Factor VIII Rabbit pAb
Synonyms:   F8; F8C; Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component
UNIPROT ID:   P00451
Background:    F8: coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Immunogen:    Synthesized peptide derived from the C-terminal region of human Factor VIII. at AA rangle: 2130-2210
Applications:    WB,IHC-P,ELISA
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 267 kDa; Observed MW: 300 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Factor VIII in HuvEc lysates using Factor VIII antibody.

Western blot analysis of Factor VIII in HuvEc lysates using Factor VIII antibody.
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