Email: info@neweastbio.com   |  Call: 6109452007

FADD Rabbit pAb

Anti-FADD Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216508

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216508
Product Name:   Anti-FADD Rabbit Polyclonal Antibody
Synonyms:   GIG3, MORT1
UNIPROT ID:   Q13158 (Gene Accession – BC000334 )
Background:    The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Immunogen:    Fusion protein of human FADD
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-150; ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 216508(FADD Antibody) at a dilution of 1/50(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 216508(Anti-FADD Antibody) at dilution 1/50.

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 216508(Anti-FADD Antibody) at a dilution of 1/50.

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with fusion protein and then with D220622(Anti-FADD Antibody) at dilution 1/50.
          Publications