Email: info@neweastbio.com   |  Call: 6109452007

FLT3 Rabbit pAb

Anti-FLT3 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217052

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217052
Product Name:   Anti-FLT3 Rabbit Polyclonal Antibody
Synonyms:   FLK2; STK1; CD135; FLK-2
UNIPROT ID:   P36888 (Gene Accession – BC126350 )
Background:    This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Immunogen:    Fusion protein of human FLT3
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 100-300;WB: 500-2000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 217052(FLT3 Antibody) at a dilution of 1/70(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 217052(Anti-FLT3 Antibody) at dilution 1/70.

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using 217052(Anti-FLT3 Antibody) at a dilution of 1/70.

In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with fusion protein and then with D221706(Anti-FLT3 Antibody) at dilution 1/70.

Gel: 6%SDS-PAGE, Lysate: 40 μg;
Lane: Mouse brain tissue lysate;
Primary antibody: 217052(FLT3 Antibody) at dilution 1/1000;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 5 minutes
          Publications