NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N225730 | ||
Product Name: Anti-FOXO4 Rabbit pAb | ||
Synonyms: FOXO4; AFX; AFX1; MLLT7; Forkhead box protein O4; Fork head domain transcription factor AFX1 | ||
UNIPROT ID: P98177 | ||
Background: The Forkhead family of transcription factors is involved in tumorigenesis of rhabdomyosarcoma and acute leukemias. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. | ||
Immunogen: A synthesized peptide derived from human FoxO4 | ||
Applications: WB,ICC/IF,IP,FC | ||
Recommended Dilutions: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100 | ||
Host Species: Rabbit | ||
Clonality: Rabbit Polyclonal | ||
Clone ID: – | ||
MW: Calculated MW: 54 kDa; Observed MW: 65 kDa | ||
Isotype: IgG | ||
Purification: Affinity Chromatography | ||
Species Reactivity: Human,Mouse,Rat | ||
Conjugation: Unconjugated | ||
Modification: Unmodified | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
Research Areas: Epigenetics and Nuclear Signaling | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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