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FOXP2 Rabbit pAb

Anti-FOXP2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S213530

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S213530
Product Name:   Anti-FOXP2 Rabbit Polyclonal Antibody
Synonyms:   SPCH1; CAGH44; TNRC10
UNIPROT ID:   O15409 (Gene Accession – NP_683697 )
Background:    This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Immunogen:    Synthetic peptide of human FOXP2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 213530(FOXP2 Antibody) at a dilution of 1/25(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 213530(Anti-FOXP2 Antibody) at dilution 1/25.
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